Role of Oxidative Stress in Liver Disorders

Oxygen is vital for life as it required many different enzymatic reactions involved in intermediate metabolism and xenobiotic biotransformation. Moreover, oxygen consumption the electron transport chain of mitochondria used to drive synthesis ATP meet energetic demands cells. However, toxic free radicals are generated byproducts molecular consumption. Oxidative stress ensues not only when production reactive species (ROS) exceeds endogenous antioxidant defense mechanism cells, but can also occur a consequence an unbalance between strategies. Given important role hepatocytes biotransformation xenobiotics, ROS represents critical event liver physiology, increasing evidence suggests that oxidative contributes development diseases. The present review, which part special issue “Oxidant Liver Diseases”, aims provide overview sources targets diseases highlights pivotal cell death. In addition, current therapies treatment options such disorders their limitations future trial design discussed.